Synthesis of acyl-hydrazone from usnic acid and isoniazid and its anti-Mycobacterium tuberculosis activity
- Melissa Barrera Tomas(corresponding author),
- Gloria Eva Tomas Chota,
- Patricia Sheen Cortavarría,
- Patricia Fuentes Bonilla,
- ,
- Julio Santiago Contreras
- Universidad Nacional Mayor de San Marcos,
- Universidad Nacional Agraria La Molina,
- Universidad Peruana Cayetano Heredia,
Research Output:
Contribution to journal
Article
Peer-review
Open access
Publication Information
Output type
Research Output:
Contribution to journal
Article
Peer-reviewOriginal language
EnglishPages from-to (Number of pages)
Pages 17-21 (5 pages)Journal (Volume, Issue Number)
Revista Colombiana de Quimica (Volume 46, Issue 3)Publication milestones
- Published - 2017
Publication status
Published - 2017
ISSN
0120-2804Publication IDs
- Scopus: 85029348693
Abstract
Compound usnic acid (1), isolated from lichen Evernia prunastri (Cajamarca-Peru) and the synthesis and characterization of its acyl-hydrazone (2), from the condensation reaction between usnic acid and isoniazid in an ethanol solution under reflux, giving an overall yield of 95%, were evaluated. Both compounds were evaluated and compared with isoniazid according to its antiMycobacterium tuberculosis activity based on the tetrazolium microplate assay (TEMA). Compound 1 had MIC (minimal inhibitory concentration) value of 16.0 μg/mL in each test of H37Rv (susceptible type), TB DM 97 (resistant wild type) and MDR DM 1098 (multi drug resistances type) strains. In similar tests, compound 2 MIC values were 2.0, 64.0 and 64.0 μg/mL respectively.
Publication metrics
Metrics
Sustainable Development Goals
SDG 3 Good Health and Well