Effect of SARS-COV-2 on kidney tissue: A narrative review
- Aldo Flores Gavino,
- Ricardo Espinoza Anchaygua,
- Percy Herrera-Añazco,
- Universidad Peruana de Ciencias Aplicadas,
- Hospital Nacional Dos de Mayo,
- Fundacion Universitaria Autonoma de las Américas,
- Universidad Tecnológica de Pereira
Open access
Publication Information
Output type
Original language
SpanishPages from-to (Number of pages)
Pages 53-57 (5 pages)Journal (Volume, Issue Number)
Acta Medica Peruana (Volume 38, Issue 1)Publication milestones
- Published - 23/05/2021
Publication status
ISSN
1018-8800Publication IDs
- Scopus: 85182304909
Abstract
We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.