MECHANISMS OF NERVE REGENERATION FOR DRUG-RESISTANT EPILEPSY: SCOPING REVIEW PROTOCOL

Drug-resistant epilepsy, affecting 30 to 40 percent of epilepsy patients, is described by the International League Against Epilepsy as “the failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules”. This condition affects patients’ quality of life and increases their mortality risk. Individuals with drug-resistant epilepsy may remain unable to achieve seizure independence until progressive degeneration is halted, and the regulatory function of interneurons is restored. Recent studies have developed techniques for modulating signaling pathways related to neural regeneration in the central nervous system, encompassing the regrowth or repair of nervous tissues, cells, or cell products. This scoping review protocol aims to evaluate the therapeutic potential of interventions that modulate nerve regeneration pathways for patients with drug-resistant epilepsy. Published studies (all publication types) will be retrieved from Web of Science, PubMed, Scopus, EBSCOhost, Ovid, and Google Scholar, spanning from database inception to the present. Studies describing patients or experimental models of drug-resistant epilepsy receiving treatments that modulate nerve regeneration pathways will be included. Studies in languages other than Spanish or English that cannot be appropriately translated or whose full-text files cannot be retrieved despite exhaustive efforts will be excluded. Eligibility assessment will be performed independently by two researchers, and results will be presented in tables. A narrative synthesis of the findings will be provided.