Hyaluronic Acid and Periodontal Disease: A Bibliometric Exploration of Global Research Output

Objective: This study aims to characterize global scientific output on the use of hyaluronic acid (HA) for treating periodontal diseases. Methods: A descriptive and exploratory bibliometric analysis was conducted using the bibliometric analysis guidelines of the Reporting and Measurement of Items for Bibliometric or Scientometric Studies in Health Sciences for health sciences. Documents published from January 2020 to October 2025 were selected from Scopus using a combined formula with controlled and free-text terms. A total of 239 publications were selected, exported, and analyzed in. comma-separated values format. Then, productivity indicators, collaboration metrics, thematic evolution analysis, and impact benchmarking were assessed using Bibliometrix (R), VOSviewer, and SciVal. Results: The scientific output exhibited a consistent annual growth rate of 17.6%. Original research articles represented the largest proportion (87%), and a very high level of collaboration was observed, involving an average of 12.4 authors per publication. Data showed an international collaboration in 25.9% of publications, suggesting an increasing globalization of the discipline. Clinical Oral Investigations was the most productive and influential journal, while Anton Sculean and Yoshinori Shirakata showed high productivity and citation impact. The thematic analysis indicated a gradual change in emphasis from classic clinical thematic areas to regenerative strategies and biomaterials, while HA, bone regeneration, and hydrogels appeared to represent major areas of research emphasis. Conclusion: The evolution of research themes and the diversity of publications reflect a dynamic, interdisciplinary landscape progressively oriented toward biomedical innovation and regenerative solutions.