High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013–2019

Rodrigo Samuel Barrientos-Yong
,
Bryan Andrei Hinojosa-Salas
,
Percy Genaro Salas-Ponce
,
Eddie Angles
,
Joaquim Ruiz
,
Maria J. Pons

Universidad Científica del Sur
,
Hospital Nacional Arzobispo Loayza
,
Medicina humana

Research Output: Contribution to journal Article Peer-review

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 248-255 (8 pages)

Journal (Volume, Issue Number)

Tropical Doctor (Volume 53, Issue 2)

Publication milestones

Accepted/In press - 2022
Published - 04/2023

Publication status

Published - 04/2023

ISSN

0049-4755

Publication IDs

Scopus: 85144228724
PubMed: 36518018

Abstract

Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.

Funding Details

The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: This work was supported by internal funds of Universidad Científica del Sur. JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT – Perú) within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica” [contract: 08-2019-FONDECYT-BM-INC-INV”]. This study has been performed within the frame of the net P220RT0168 from Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED).

FundersFunding numbers

Servicios del Sistema Nacional de Ciencia,Tecnología e Innovación Tecnológica

08-2019-FONDECYT-BM-INC-INV

UCSUR: UCS-

FONDECYT