Genital warts in Burmeister's porpoises: Characterization of Phocoena spinipinnis papillomavirus type 1 (PsPV-1) and evidence for a second, distantly related PsPV
- Marie Françoise Van Bressem(corresponding author),
- Patricia Cassonnet,
- Annabel Rector,
- Christian Desaintes,
- Koen Van Waerebeek,
- CEPEC/Museo de Delfines,
- Institut Pasteur, Paris,
- Rega Institute for Medical Research,
- Nuclear Research Centre (SCK-CEN),
- ,
- Pro Delphinus
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 1928-1933 (6 pages)Journal (Volume, Issue Number)
Journal of General Virology (Volume 88, Issue 7)Publication milestones
- Published - 07/2007
Publication status
ISSN
0022-1317Publication IDs
- Scopus: 34347345136
- PubMed: 17554024
Abstract
We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized Phocoena spinipinnis papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54-55%) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and Tursiops truncatus papillomavirus type 2 (TtPV-2). This warrants the classification of PsPV-1 as the prototype of the genus Omikronpapillomavirus. PsPV-1 clustered with TtPV-2 in the E6 and E1 E2 phylogenetic trees and with TtPV-2 and BPV-3 in the L2L1 tree. This supports the hypothesis that PV evolution may not be monophyletic across ali genes.