Genetics and genomics in Peru: Clinical and research perspective
- Heinner Guio,
- Julio A. Poterico,
- Kelly S. Levano,
- Mario Cornejo-Olivas,
- Pilar Mazzetti,
- Gioconda Manassero-Morales
- Instituto Nacional de Salud, Lima,
- Universidad Científica del Sur,
- Instituto Nacional de Salud del Niño San Borja,
- INBIOMEDIC Research and Technological Center,
- docencia y atención especializada en epilepsia,
- Universidad Nacional Mayor de San Marcos
Research Output:
Contribution to journal
Article
Peer-review
Open access
Publication Information
Output type
Research Output:
Contribution to journal
Article
Peer-reviewOriginal language
EnglishPages from-to (Number of pages)
Pages 873-886 (14 pages)Journal (Volume, Issue Number)
Molecular Genetics and Genomic Medicine (Volume 6, Issue 6)Publication milestones
- Published - 11/2018
Publication status
Published - 11/2018
Publication IDs
- Scopus: 85059064931
- PubMed: 30584990
Funding Details
By 2011, the Peruvian National Institute of Health (Instituto Nacional de Salud del Peru) started the Peruvian Genome Project lead by Dr. Heinner Guio in collaboration with Timothy O'Connor from University of Maryland and Dr. Tarazona from Universidade Federal de Minas Gerais. Despite disparities in research cost (e.g., equipment and supplies) as compared to US (more than 2.5 times) (Sirisena & Dissanayake, 2018), a total of 280 genomes from 17 Native and 13 Mestizo populations have been analyzed (150 genomes were sequenced using whole genome sequencing and 130 using genotype array platform). This study represents the most extensive Native American sequencing project to date. The analysis shows that our Mestizo populations have 60%–70% native genes—in some geographical locations more than 80%. Most of the newly identified SNPs are mis-sense (~60,000) and come from native communities (Harris et al., 2018). Our data demonstrate a high Native ancestry component in the Peruvian population, even as compared to the results obtain in the Mexican genomic project (Belbin, Nieves‐Colón, Kenny, Moreno‐Estrada, & Gignoux, 2018). Additional studies in genomics of Peruvian populations will help us to understand these new SNPs (Elhaik et al., 2014; Sandoval et al., 2013). No doubt, these new findings from the Peruvian Genome project will enhance genetic research and medical genomics not only for Peruvians, but for Hispanics and Latinos.
FundersFunding numbers
Peruvian National Institute of Health
-University of Maryland
-Instituto Nacional del Cáncer
-Access to documents
Publication metrics
Metrics
PlumX, opens in new tab
Social media
53
Citations
20
Captures
75