Generalized pustular psoriasis triggered by Zika virus infection
- A. E. Paniz Mondolfi(corresponding author),
- M. Hernandez Perez,
- G. Blohm,
- M. Marquez,
- A. Mogollon Mendoza,
- C. E. Hernandez-Pereira
- Hospital Internacional Barquisimeto,
- Instituto de Biomedicina / Instituto Venezolano de los Seguros Sociales (IVSS),
- Miraca Life Sciences Research Institute/Tufts Medical Center,
- College of Liberal Arts and Sciences,
- Universidad Centroccidental Lisandro Alvarado,
- Infectious Diseases Research Incubator and the Zoonosis and Emerging Pathogens Regional Collaborative Network
Publication Information
Output type
Original language
EnglishPages from-to (Number of pages)
Pages 171-174 (4 pages)Journal (Volume, Issue Number)
Clinical and Experimental Dermatology (Volume 43, Issue 2)Publication milestones
- Published - 03/2018
Publication status
ISSN
0307-6938Publication IDs
- Scopus: 85031317984
- PubMed: 29027743
Abstract
Zika virus is an emerging arbovirus, which is expanding in epidemic proportions through tropical and subtropical areas of the world. Although Zika is linked to a number of congenital and neurological complications, there is scarce knowledge on the impact of ZIKV infection in human skin. We report the case of a 68-year old woman who presented with generalized pustular psoriasis after a preceding and otherwise uneventful episode of ZIKV infection. Based on recent experimental data on the biology of ZIKV infection in the cutaneous environment, we speculate that ZIKV may have directly triggered the development of generalized pustular psoriasis by stimulation of keratinocyte-derived mediators of inflammation and a polyfunctional T-cell driven immune reaction in the cutaneous milieu.
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SDG 3 Good Health and Well