MELAS in Latin America
Original title: Enfermedad de MELAS en Latinoamérica: revisión temática
- Wilfor Aguirre-Quispe,
- Mariana Valdez-Taboada,
- Luis Urbina-Ramírez,
- Andrea Rivera-Valdivia,
- Elison Sarapura-Castro,
- Julio Montoya
- docencia y atención especializada en epilepsia,
- Fogarty Interdisciplinary Cerebrovascular Diseases Training Program in South America,
- Fogarty Northern Pacific Global Health Fellows Program,
- Universidad de Zaragoza,
- Universidad Peruana Cayetano Heredia
Research Output:
Contribution to journal
Review article
Peer-review
Open access
Publication Information
Output type
Research Output:
Contribution to journal
Review article
Peer-reviewOriginal language
SpanishPages from-to (Number of pages)
Pages 316-332 (17 pages)Journal (Volume, Issue Number)
Revista de Neuro-Psiquiatria (Volume 84, Issue 4)Publication milestones
- Published - 10/2021
Publication status
Published - 10/2021
ISSN
0034-8597Publication IDs
- Scopus: 85176898748
Abstract
A thematic review on MELAS in Latin America between 1990 and 2021 was conducted through a systematic literature search on LILACs, Scielo, PubMed/Medline and Scopus databases. Nineteen case reports/series out of 966 publications were selected and included 51 patients, 42 of them with genetic diagnosis reported in eight Latin American countries. The m.3243A> G variant was the most frequently reported, the mean age at onset being 12 ± 9.7 years, with a mild female predominance. The most frequent neurological features were stroke-like episodes and seizures. Neuroimaging tests highlighted ischemic stroke-like lesions as well as calcified lesions in the basal ganglia.
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Sustainable Development Goals
SDG 3 Good Health and Well