Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
- Clodagh Towns,
- Madeleine Richer,
- Simona Jasaityte,
- Eleanor J. Stafford,
- Julie Joubert,
- Tarek Antar
- UCL Queen Square Institute of Neurology,
- University College London,
- National Institute on Aging (NIA),
- NIH,
- The Michael J. Fox Foundation for Parkinson's Research,
- Data Tecnica International
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Research Output:
Contribution to journal
Article
Peer-reviewOriginal language
EnglishArticle number
131Journal (Volume, Issue Number)
npj Parkinson's Disease (Volume 9, Issue 1)Publication milestones
- Published - 12/2023
Publication status
Published - 12/2023
Publication IDs
- Scopus: 85170643330
Abstract
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
Funding Details
This research is supported by the Aligning Science Across Parkinson’s Initiative, the Intramural Research Program, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949, and the Michael J. Fox Foundation for Parkinson’s Research. Data used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org .
A.B.S. and C.B. are supported by the Intramural Research Program of the National Institute on Aging and have received grant support from the Michael J. Fox Foundation for Parkinson’s Research and the Aligning Science Across Parkinson’s Initiative. A.B.S. has received royalty payments related to a diagnostic for stroke. A.B.S. is an editor for npj Parkinson’s Disease. A.B.S. was not involved in the journal’s review of, or decisions related to, this manuscript. H.L., H.I., D.V., K.L., and M.A.N. are consultants employed by Data Tecnica International. Data Tecnica is engaged in a consulting agreement with the US National Institutes of Health. H.R.M. is employed by UCL. In the last 24 months, he reports paid consultancy from Biogen, Biohaven, Lundbeck; lecture fees/honoraria from Wellcome Trust, Movement Disorders Society; Research Grants from Parkinson’s UK, Cure Parkinson’s Trust, PSP Association, CBD Solutions, Drake Foundation, Medical Research Council, Michael J. Fox Foundation. H.R.M. is also a co-applicant on a patent application related to C9ORF72—Method for diagnosing a neurodegenerative disease (PCT/GB2012/052140). BC and JS are employed by the Michael J. Fox Foundation for Parkinson’s Research. All other authors declare no financial or non-financial competing interests.
FundersFunding numbers
Aligning Science Across Parkinson’s Initiative
-Parkinson’s UK, Cure Parkinson’s Trust
-NIH
-HHS
ZO1 AG000949
NIA
-MJFF
-MDS
-WT
-PSPA
-ASAP
-PCB Solutions
-MRC
-Drake Foundation
-Access to documents
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