Cloning and nucleotide sequence analysis of a gene encoding an OXA- derived β-lactamase in Acinetobacter baumannii
- Jordi Vila(corresponding author),
- Margarita Navia,
- ,
- Climent Casals
- Hospital Clínic – Universitat de Barcelona,
Research Output:
Contribution to journal
Comment/debate
Open access
Publication Information
Output type
Research Output:
Contribution to journal
Comment/debate
Original language
EnglishPages from-to (Number of pages)
Pages 2757-2759 (3 pages)Journal (Volume, Issue Number)
Antimicrobial Agents and Chemotherapy (Volume 41, Issue 12)Publication milestones
- Published - 12/1997
Publication status
Published - 12/1997
ISSN
0066-4804Publication IDs
- Scopus: 0030777048
- PubMed: 9420053
Abstract
A clinical strain of Acinetobacter baumannii (strain Ab41) that was resistant to all β-lactam antibiotics tested except ceftazidime, ceftriaxone, ceftizoxime, and imipenam produced three β-lactamases: a presumptive chromosomal cephalosporinase, a TEM-1-like β-lactamase (pI 5.4), and a novel OXA-derived β-lactamase named OXA-21 (pI 7.0). The gene encoding OXA-21 was located in an integron. The nucleotide sequence showed three mutations compared with the sequence of OXA-3, with two being silent; the nonsilent mutation generated a substitution of Ile-217 to Met.
Access to documents
Publication metrics
Metrics
PlumX, opens in new tab
Citations
61
Captures
33
Sustainable Development Goals
SDG 3 Good Health and Well