Functioning adrenocortical carcinoma: a peruvian case series

Introduction: Adrenocortical carcinoma (ACC), the second most common malignant endocrine tumor, arises from the adrenal cortex and is primarily diagnosed in middleaged individuals. Functioning ACC often presents with hyperandrogenism, with or without hypercortisolism. Approximately 50% of cases are functioning. Case report: We present the cases of two adult women who exhibited hyperandrogenism and a giant abdominal mass on physical examination. The diagnosis of ACC was confirmed through histopathological analysis. Discussion: Functioning ACC typically presents with a large abdominal mass and elevated adrenal hormone levels. Diagnosis involves hormonal testing and imaging studies. CT imaging is essential for the initial assessment of ACC, as it can detect features such as mass heterogeneity, and assess potential infiltration. Treatment generally involves surgical resection for localized tumors or chemotherapy for advanced cases. Survival rates decrease in advanced stages and with larger tumor sizes. Conclusion: ACC should be considered in the differential diagnosis of abdominal masses accompanied by hyperandrogenism.