CNS symptoms in myotonic dystrophy type 1 (DM1): report of three cases
- Celia Jara-Velásquezc(Author),
- Kattia Alfaro-Vásquezc(Author),
- Gabriela Espinoza-Morónb(Author),
- Richard S. Rodriguezc(Author),
- Andrea Rivera-Valdiviab, c(Author),
- Milagros Galecio-Castillob(Author)
- ,
- bUniversidad Científica del Sur,
- cdocencia y atención especializada en epilepsia
Research Output: Contribution to journal Article Peer-review
Open access
Publication Information
Output type
Research Output: Contribution to journal Article Peer-review
Original language
EnglishPages from-to (Number of pages)
Pages 420-429 (10 pages)Journal (Volume, Issue Number)
Revista de Neuro-Psiquiatria (Volume 88, Issue 4)Publication milestones
- Published - 06/02/2026
Publication status
Published - 06/02/2026
ISSN
0034-8597External Publication IDs
- Scopus: 105030393143
Abstract
Myotonic dystrophy type 1 is an autosomal dominant hereditary neuromuscular disorder with systemic manifestations. It is characterized by progressive muscle weakness, myotonia, and cataracts, alongside variable involvement of the cardiovascular, endocrine, and central nervous systems. This report highlights three cases of myotonic dystrophy type 1 with significant central nervous system involvement, presenting with structural changes in brain MRI, cognitive decline, epilepsy, and behavioral changes. These cases underscore the importance of a multidisciplinary evaluation, including neuropsychiatric assessments and neuroimaging studies, as an integral part of the comprehensive management of these patients.
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