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Seizures in patients with spinocerebellar ataxias: insights from a specialized institute in Peru

  • Alonso Abad
    ,
  • Ana Saldarriaga-Mayo
    ,
  • Ismael Araujo-Aliaga
    ,
  • Andrea Rivera-Valdivia
    ,
  • Elison Sarapura-Castro
    ,
  • Universidad Científica del Sur
    ,
  • docencia y atención especializada en epilepsia
    ,
Research Output:
Contribution to journal
Article
Peer-review

Open access

Publication Information

Output type

Research Output:
Contribution to journal
Article
Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 107-115 (9 pages)

Journal (Volume, Issue Number)

Revista de Neuro-Psiquiatria (Volume 89, Issue 2)

Publication milestones

  • Published - 01/2026

Publication status

Published - 01/2026

ISSN

0034-8597

Publication IDs

  • Scopus: 105039168416

Abstract

Objective: To compare the frequency of seizures between patients with SCA10 and other SCA in a sample of the Peruvian population. Materials and methods: Observational study with a retrospective component through medical record review and a prospective component with interviews after prior informed consent. Patients with a genetic diagnosis of SCA attended between January 2014 and December 2023 in a national referral center in Peru were recruited. Results: We identified 125 cases from 87 families diagnosed with six types of SCA (SCA1, SCA2, MJD/SCA3, SCA6, SCA7 and SCA10), with an overall seizure frequency of 11.2%. Seizures predominated in the SCA10 subgroup (16%), contrasting with the other SCA subgroup (4%), which had only two cases of seizures in SCA2. Conclusions: Seizures are significantly more frequent in SCA10 compared to other SCA subgroup in the studied population. Tonic-clonic of unknown onset seizures are common in SCA10, while focal onset motor seizures were described in SCA2, most of them with good response with antiseizure medications.

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