Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii
- Margarita M. Navia,
- ,
- Jordi Vila(corresponding author)
- Hospital Clínic – Universitat de Barcelona,
- ,
- Hospital Clinic Barcelona
Research Output:
Contribution to journal
Article
Peer-reviewPublication Information
Output type
Research Output:
Contribution to journal
Article
Peer-reviewOriginal language
EnglishPages from-to (Number of pages)
Pages 261-265 (5 pages)Journal (Volume, Issue Number)
Microbial Drug Resistance (Volume 8, Issue 4)Publication milestones
- Published - 2002
Publication status
Published - 2002
ISSN
1076-6294Publication IDs
- Scopus: 0036929877
- PubMed: 12523622
Abstract
Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.
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