A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates

Joaquim Ruiz
,
Asunción Moreno
,
M. Teresa Jimenez De Anta
,
Jordi Vila(corresponding author)

*Corresponding author for this work

Medicina humana
,
Hospital Clinic Barcelona

Research Output:

Contribution to journal

Article

Peer-review

Publication Information

Output type

Research Output:

Contribution to journal

Article

Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 542-545 (4 pages)

Journal (Volume, Issue Number)

International Journal of Antimicrobial Agents (Volume 25, Issue 6)

Publication milestones

Published - 06/2005

Publication status

Published - 06/2005

ISSN

0924-8579

Publication IDs

Scopus: 19544371363
PubMed: 15876526

Abstract

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation.

Funding Details

This work has been partially supported by grants FIS02/0353 from the Ministry of Health, Spain, and 2002 SGR00121 from the Departament d’Universitats, Recerca I Societat de la Informació de la Generalitat de Catalunya, Spain. J.R. has a fellowship from RICET.

FundersFunding numbers

Departament d’Universitats, Recerca I Societat de la Informació de la Generalitat de Catalunya, Spain

RICET

Ministerio de Sanidad, Servicios Sociales e Igualdad

2002 SGR00121