Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii

Jordi Vila, Joaquim Ruiz, Pilar Goñi, Teresa Jimenez De Anta

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

160 Citas (Scopus)

Resumen

Mutations in the parC gene, which encodes a subunit of topoisomerase IV, were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone-resistance-determining region of the parC gene from A. baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of ≤ 32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys. These results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A. baumannii highly resistant to quinolones.

Idioma originalInglés
Páginas (desde-hasta)757-762
Número de páginas6
PublicaciónJournal of Antimicrobial Chemotherapy
Volumen39
N.º6
DOI
EstadoPublicada - 1997

Huella

Profundice en los temas de investigación de 'Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii'. En conjunto forman una huella única.

Citar esto