TY - JOUR
T1 - Presence of Extended-Spectrum β-lactamase, CTX-M-65 in Salmonella enterica serovar Infantis Isolated from Children with Diarrhea in Lima, Peru
AU - Granda, Ana
AU - Riveros, Maribel
AU - Martínez-Puchol, Sandra
AU - Ocampo, Karen
AU - Laureano-Adame, Laura
AU - Corujo, Alfredo
AU - Reyes, Isabel
AU - Ruiz, Joaquim
AU - Ochoa, Theresa J.
N1 - Publisher Copyright:
© 2019 by Georg Thieme Verlag KG, Stuttgart. New York.
PY - 2019
Y1 - 2019
N2 - Gastroenteritis in children is a serious condition in many parts of the world. Salmonella enterica is one of the causes of the disease. In this study, 280 fecal samples from children with diarrhea in four hospitals in Lima, Peru, were collected between September 2012 and March 2013. Salmonella was detected in 26 of the samples. Serotyping demonstrated that 25 of the isolates were S. enterica Infantis, and one isolate was S. enterica Typhimurium. Repetitive extragenic palindromic-polymerase chain reaction analysis suggests that all S. Infantis belong to the same clone. All but one of the S. Infantis isolates exhibited an extended-spectrum β-lactamase phenotype as they harbored bla CTX-M 65. Two strains also carried bla TEM-1. Nine of the isolates were resistant to azithromycin and two to ciprofloxacin. This study demonstrates that a multidrug-resistant S. Infantis clone carrying bla CTX-M 65 was circulating among children in Lima, Peru. The development of molecular epidemiology studies in Salmonella -causing diarrhea or other pathologies in Lima and in other areas will be useful to determine the permanence, geographical spread, and clinical implications of this clone.
AB - Gastroenteritis in children is a serious condition in many parts of the world. Salmonella enterica is one of the causes of the disease. In this study, 280 fecal samples from children with diarrhea in four hospitals in Lima, Peru, were collected between September 2012 and March 2013. Salmonella was detected in 26 of the samples. Serotyping demonstrated that 25 of the isolates were S. enterica Infantis, and one isolate was S. enterica Typhimurium. Repetitive extragenic palindromic-polymerase chain reaction analysis suggests that all S. Infantis belong to the same clone. All but one of the S. Infantis isolates exhibited an extended-spectrum β-lactamase phenotype as they harbored bla CTX-M 65. Two strains also carried bla TEM-1. Nine of the isolates were resistant to azithromycin and two to ciprofloxacin. This study demonstrates that a multidrug-resistant S. Infantis clone carrying bla CTX-M 65 was circulating among children in Lima, Peru. The development of molecular epidemiology studies in Salmonella -causing diarrhea or other pathologies in Lima and in other areas will be useful to determine the permanence, geographical spread, and clinical implications of this clone.
KW - Salmonella enterica serovar Infantis
KW - diarrhea
KW - extended-spectrum β-lactamases
UR - http://www.scopus.com/inward/record.url?scp=85070104460&partnerID=8YFLogxK
U2 - 10.1055/s-0039-1685502
DO - 10.1055/s-0039-1685502
M3 - Artículo
AN - SCOPUS:85070104460
SN - 1305-7707
VL - 14
SP - 194
EP - 200
JO - Journal of Pediatric Infectious Diseases
JF - Journal of Pediatric Infectious Diseases
IS - 4
ER -
