Molecular epidemiology of macrolide and tetracycline resistances in commensal Gemella sp. isolates

Paula Cerdá Zolezzi, Pilar Goñi Cepero, Joaquim Ruiz, Leticia Millán Laplana, Carmen Rubio Calvo, Rafael Gómez-Lus

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

The epidemiologic relatedness of 29 erythromycin-resistant Gemella sp. strains from normal flora, characterized previously, were evaluated by pulsed-field gel electrophoresis (PFGE). Three isolates carried the tet(O) gene and the tet(M) gene. The msr(A) gene was found in two Gemella morbillorum strains in combination with the erm(B) or mef(E) gene. The sequences of the mef(A/E), erm(B), and msr(A) genes showed a high similarity to the corresponding sequences of other gram-positive cocci. All the strains harboring the mef(A/E) gene and the msr(D) gene possessed open reading frame 3 (ORF3)/ORF6. The 16 G. morbillorum isolates represented 15 distinct DNA profiles. Four clusters were identified (≥80% genetic relatedness). The 12 Gemella haemolysans strains belonged to different PFGE types. The clonal diversity found suggests that horizontal transfer may be the main route through which erythromycin resistance is acquired.

Idioma originalInglés
Páginas (desde-hasta)1487-1490
Número de páginas4
PublicaciónAntimicrobial Agents and Chemotherapy
Volumen51
N.º4
DOI
EstadoPublicada - abr. 2007

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