Metabolic abnormalities are common among South American hispanics subjects with normal weight or excess body weight: The CRONICAS cohort study

Catherine P. Benziger, Antonio Bernabé-Ortiz, Robert H. Gilman, William Checkley, Liam Smeeth, Germán Málaga, J. Jaime Miranda, Juan P. Casas, George Davey Smith, Shah Ebrahim, Héctor H. García, Luis Huicho, Víctor M. Montori, Gregory B. Diette, Fabiola León-Velarde, María Rivera, Robert A. Wise

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27 Citas (Scopus)


Objective: We aimed to characterize metabolic status by body mass index (BMI) status. Methods: The CRONICAS longitudinal study was performed in an age-and-sex stratified random sample of participants aged 35 years or older in four Peruvian settings: Lima (Peru's capital, costal urban, highly urbanized), urban and rural Puno (both high-altitude), and Tumbes (costal semirural). Data from the baseline study, conducted in 2010, was used. Individuals were classified by BMI as normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), and obese (≥30 kg/m2), and as metabolically healthy (0-1 metabolic abnormality) or metabolically unhealthy (≥2 abnormalities). Abnormalities included individual components of the metabolic syndrome, high-sensitivity C-reactive protein, and insulin resistance. Results: A total of 3088 (age 55.6±12.6 years, 51.3%females) had all measurements. Of these, 890 (28.8%), 1361 (44.1%) and 837 (27.1%) were normal weight, overweight and obese, respectively. Overall, 19.0%of normal weight in contrast to 54.9%of overweight and 77.7%of obese individuals had ≥3 risk factors (p<0.001). Among normal weight individuals, 43.1% were metabolically unhealthy, and age ≥65 years, female, and highest socioeconomic groups were more likely to have this pattern. In contrast, only 16.4%of overweight and 3.9% of obese individuals were metabolically healthy and, compared to Lima, the rural and urban sites in Puno were more likely to have a metabolically healthier profile. Conclusions: Most Peruvians with overweight and obesity have additional risk factors for cardiovascular disease, as well as a majority of those with a healthy weight. Prevention programs aimed at individuals with a normal BMI, and those who are overweight and obese, are urgently needed, such as screening for elevated fasting cholesterol and glucose.

Idioma originalInglés
Número de artículoe0138968
PublicaciónPLoS ONE
EstadoPublicada - 1 nov. 2015
Publicado de forma externa


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