TY - JOUR
T1 - Mechanisms of resistance to quinolones
T2 - Target alterations, decreased accumulation and DNA gyrase protection
AU - Ruiz, Joaquim
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.
AB - Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.
KW - DNA gyrase
KW - Efflux pumps
KW - Quinolone resistance
KW - Topoisomerase IV
KW - qnr
UR - http://www.scopus.com/inward/record.url?scp=0038440791&partnerID=8YFLogxK
U2 - 10.1093/jac/dkg222
DO - 10.1093/jac/dkg222
M3 - Artículo de revisión
C2 - 12697644
AN - SCOPUS:0038440791
SN - 0305-7453
VL - 51
SP - 1109
EP - 1117
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 5
ER -
