TY - JOUR
T1 - Increased resistance to quinolones in Campylobacter jejuni
T2 - A genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates
AU - Ruiz, Joaquim
AU - Goñi, Pilar
AU - Marco, Francesc
AU - Gallardo, Francesc
AU - Mirelis, Beatriz
AU - Jimenez De Anta, Teresa
AU - Vila, Jordi
PY - 1998
Y1 - 1998
N2 - Campylobacter jejuni is a frequent cause of enteritis and sometimes it requires antimicrobial therapy. We have studied the evolution of resistance to nine antibiotics from 1990 to 1994 and investigated how frequently gyrA mutations are involved in the acquisition of quinolone resistance. The percentage of chloramphenicol-, clindamycin-, tertracycline- and amoxicillin plus clavulanic acid-resistant strains has remained practically unchanged and erythromycin and gentamicin resistance has decreased, whereas the percentage of ampicillin-, nalidixic acid- or ciprofloxacin-resistant strains has almost doubled in the follow-up period, from 56 to 76% for ampicillin- and from 47.5 to 88% for quinolone-resistant strains. This study clearly shows that a mutation in Thr-86 to Ile or Lys is a frequent mechanism associated with the acquisition of a high level of resistance to quinolones in clinical isolates of C. jejuni.
AB - Campylobacter jejuni is a frequent cause of enteritis and sometimes it requires antimicrobial therapy. We have studied the evolution of resistance to nine antibiotics from 1990 to 1994 and investigated how frequently gyrA mutations are involved in the acquisition of quinolone resistance. The percentage of chloramphenicol-, clindamycin-, tertracycline- and amoxicillin plus clavulanic acid-resistant strains has remained practically unchanged and erythromycin and gentamicin resistance has decreased, whereas the percentage of ampicillin-, nalidixic acid- or ciprofloxacin-resistant strains has almost doubled in the follow-up period, from 56 to 76% for ampicillin- and from 47.5 to 88% for quinolone-resistant strains. This study clearly shows that a mutation in Thr-86 to Ile or Lys is a frequent mechanism associated with the acquisition of a high level of resistance to quinolones in clinical isolates of C. jejuni.
KW - Antibiotics
KW - Campylobacter jejuni
KW - GyrA
KW - Quinolone resistance
UR - http://www.scopus.com/inward/record.url?scp=2642593023&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.1998.tb02274.x
DO - 10.1111/j.1348-0421.1998.tb02274.x
M3 - Artículo
C2 - 9580533
AN - SCOPUS:2642593023
SN - 0385-5600
VL - 42
SP - 223
EP - 226
JO - Microbiology and Immunology
JF - Microbiology and Immunology
IS - 3
ER -