In vitro fluoroquinolone-resistant mutants of Salmonella enterica serotype Enteritidis: Analysis of mechanisms involved in resistance

Sara M. Soto, Joaquim Ruíz, M. Carmen Mendoza, Jordi Vila

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

26 Citas (Scopus)

Resumen

This study analysed the mechanisms involved in the acquisition of resistance to quinolones in mutants obtained in vitro of Salmonella enterica serotype Enteritidis. Two nalidixic acid-resistant (minimal inhibitory concentrations, MIC>256 mg/l), ciprofloxacin-susceptible (MIC 0.5 mg/l) clinical isolates of Salmonella Enteritidis with a mutation at amino acid codon Ser-83 of the gyrA gene were grown on plates containing increasing concentrations of ciprofloxacin. The increase in MIC to ciprofloxacin, sparfloxacin and trovafloxacin was totally or partially associated with over-expression of an AcrAB-like efflux pump. In addition, unidentified mechanism(s) may have been involved in the increased MIC to these antimicrobials. This study demonstrated that AcrAB-like efflux pumps appear to play a relevant role in the increase in MIC to some quinolones although, other, as yet undefined, mechanisms may be involved.

Idioma originalInglés
Páginas (desde-hasta)537-540
Número de páginas4
PublicaciónInternational Journal of Antimicrobial Agents
Volumen22
N.º5
DOI
EstadoPublicada - nov. 2003

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