Dengue and COVID-19 Co-Circulation in the Peruvian Amazon: A Population-Based Study

Maria J. Pons, Ana Mayanga-Herrera, Gabriela M. Ulloa, Barbara Ymaña, Sabrina Medina, Freddy Alava, Carlos Alvarez-Antonio, Graciela Meza-Sanchez, Carlos Calampa, Wilma Casanova, Cristiam Carey, Hugo Rodrıguez-Ferrucci, Amy C. Morrison, Antonio M. Quispe

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

The COVID-19 pandemic affected the main Amazon cities dramatically, with Iquitos City reporting the highest seroprevalence of anti-SARS-CoV-2 antibodies during the first COVID-19 wave worldwide. This phenomenon raised many questions about the possibility of a co-circulation of dengue and COVID-19 and its consequences. We carried out a population-based cohort study in Iquitos, Peru. We obtained a venous blood sample from a subset of 326 adults from the Iquitos COVID-19 cohort (August 13–18, 2020) to estimate the seroprevalence of anti-dengue virus (DENV) and anti-SARS-CoV-2 antibodies. We tested each serum sample for anti-DENV IgG (serotypes 1, 2, 3, and 4) and SARS-CoV-2 antibodies anti-spike IgG and IgM by ELISA. We estimated an anti-SARS-CoV-2 seroprevalence of 78.0% (95% CI, 73.0–82.0) and an anti-DENV seroprevalence of 88.0% (95% CI, 84.0–91.6), signifying a high seroprevalence of both diseases during the first wave of COVID-19 transmission in the city. The San Juan District had a lower anti-DENV antibody seroprevalence than the Belen District (prevalence ratio, 0.90; 95% CI, 0.82–0.98). However, we did not observe these differences in anti-SARS-CoV-2 antibody seroprevalence. Iquitos City presented one of the highest seroprevalence rates of anti-DENV and anti-SARS-CoV-2 antibodies worldwide, but with no correlation between their antibody levels.

Idioma originalInglés
Páginas (desde-hasta)1249-1255
Número de páginas7
PublicaciónAmerican Journal of Tropical Medicine and Hygiene
Volumen108
N.º6
DOI
EstadoPublicada - 2023

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