TY - JOUR
T1 - COVID-19 breakthrough infections in type 1 diabetes mellitus
T2 - a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group
AU - COVAD Study Group
AU - Panchawagh, Suhrud
AU - Ravichandran, Naveen
AU - Barman, Bhupen
AU - Nune, Arvind
AU - Javaid, Mahnoor
AU - Gracia-Ramos, Abraham Edgar
AU - Day, Jessica
AU - Joshi, Mrudula
AU - Kuwana, Masataka
AU - Saha, Sreoshy
AU - Pande, Arunkumar R.
AU - Caballero-Uribe, Carlo Vinicio
AU - Velikova, Tsvetelina
AU - Parodis, Ioannis
AU - Knitza, Johannes
AU - Kadam, Esha
AU - Tan, Ai Lyn
AU - Shinjo, Samuel Katsuyuki
AU - Boro, Hiya
AU - Sen, Parikshit
AU - Day, Jessica
AU - Nikiphorou, Elena
AU - Ziade, Nelly
AU - Milchert, Marcin
AU - Cavagna, Lorenzo
AU - Chen, Yi Ming
AU - Makol, Ashima
AU - Agarwal, Vishwesh
AU - Patel, Aarat
AU - Pauling, John D.
AU - Wincup, Chris
AU - Tehozol, Erick Adrian Zamora
AU - Serrano, Jorge Rojas
AU - La Torre, Ignacia García De
AU - Colunga-Pedraza, Iris J.
AU - Merayo-Chalico, Javier
AU - Chibuzo, Okwara Celestine
AU - Katchamart, Wanruchada
AU - Goo, Phonpen Akawatcharangura
AU - Shumnalieva, Russka
AU - Hoff, Leonardo Santos
AU - El Kibbi, Lina
AU - Halabi, Hussein
AU - Vaidya, Binit
AU - Shaharir, Syahrul Sazliyana
AU - Hasan, ATMTanveer T.M.T.
AU - Dey, Dzifa
AU - Gutiérrez, Carlos Enrique Toro
AU - Lilleker, James B.
AU - Ugarte-Gil, Manuel Francisco
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated cohort, 16 (16%) T1DM patients had one BI and 2 (2%) had two BIs. No morbidities or deaths were reported, except for one patient who required hospitalization with oxygen without admission to intensive care. The frequency, clinical features, and severity of BIs were not significantly different between T1DM patients and HCs after adjustment for confounding factors. Our study did not show any statistically significant differences in the frequency, symptoms, duration, or critical care requirements between T1DM and HCs after COVID-19 vaccination. Further research is needed to identify factors associated with inadequate vaccine response in patients with BIs, especially in patients with autoimmune diseases.
AB - To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated cohort, 16 (16%) T1DM patients had one BI and 2 (2%) had two BIs. No morbidities or deaths were reported, except for one patient who required hospitalization with oxygen without admission to intensive care. The frequency, clinical features, and severity of BIs were not significantly different between T1DM patients and HCs after adjustment for confounding factors. Our study did not show any statistically significant differences in the frequency, symptoms, duration, or critical care requirements between T1DM and HCs after COVID-19 vaccination. Further research is needed to identify factors associated with inadequate vaccine response in patients with BIs, especially in patients with autoimmune diseases.
KW - Breakthrough infections
KW - COVID-19
KW - Survey
KW - Type 1 diabetes mellitus
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85181481512&partnerID=8YFLogxK
U2 - 10.1007/s00296-023-05496-y
DO - 10.1007/s00296-023-05496-y
M3 - Artículo
C2 - 38060005
AN - SCOPUS:85181481512
SN - 0172-8172
VL - 44
SP - 73
EP - 80
JO - Rheumatology International
JF - Rheumatology International
IS - 1
ER -