Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

Margarita M. Navia; Joaquim Ruiz; Jordi Vila

doi:10.1089/10766290260469516

Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

Margarita M. Navia, Joaquim Ruiz, Jordi Vila

Medicina humana

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

47 Citas (Scopus)

Resumen

Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

Idioma original	Inglés
Páginas (desde-hasta)	261-265
Número de páginas	5
Publicación	Microbial Drug Resistance
Volumen	8
N.º	4
DOI	https://doi.org/10.1089/10766290260469516
Estado	Publicada - 2002

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abstract = "Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.",

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AB - Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

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Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

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