Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: A propensity score analysis

Gabriel De-La-Cruz-Ku, Bryan Valcarcel, Zaida Morante, Mecker G. Möller, Sofia Lizandro, Lia P. Rebaza, Daniel Enriquez, Renato Luque, María G. Luján-Peche, Miguel E. Eyzaguirre-Sandoval, Antonella Saavedra, Cesar Razuri, Joseph A. Pinto, Hugo A. Fuentes, Silvia P. Neciosup, Henry L. Gomez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

7 Citas (Scopus)

Resumen

BACKGROUND: Breast-conserving surgery (BCS) as an alternative to total mastectomy (TM) in patients with early-stage triple-negative breast cancer (TNBC) is not widely spread. OBJECTIVE: We aimed to compare the overall survival (OS) and disease-free survival (DFS) between both surgical approaches in early-stage TNBC patients at 10 years. METHODS: We conducted a retrospective cohort study in TNBC female patients with stage I-IIa, treated at a single-center during the period of 2000-2014. We estimated and compared the survival rates with the Kaplan Meier and Long-rank test. Propensity scores were calculated with the generalized boosted regression model and were used in the multivariate Cox regression analysis with the covariate adjustment method. RESULTS: We included 288 patients, 111 in the BCS vs. 177 in the TM group. The median follow-up was 102 months. Moreover, the patients in the BCS group had superior OS (85% vs. 81%, p = 0.56) and DFS (83% vs. 80%, p = 0.42) at 10 years. In the multivariate Cox analysis, BCS decreased the mortality risk (HR: 0.79, 95% CI: 0.37-1.67, p = 0.538), and the locoregional or distant recurrence risk (HR: 0.67, 95% CI: 0.32-1.41, p = 0.294), albeit with no statistical significance. CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC.

Idioma originalInglés
Páginas (desde-hasta)29-35
Número de páginas7
PublicaciónBreast Disease
Volumen39
N.º1
DOI
EstadoPublicada - 2020

Huella

Profundice en los temas de investigación de 'Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages: A propensity score analysis'. En conjunto forman una huella única.

Citar esto