TY - JOUR
T1 - Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection
T2 - A Systematic Review and Meta-Analysis
AU - Rani, Isha
AU - Satapathy, Prakasini
AU - Goyal, Anmol
AU - Shamim, Muhammad Aaqib
AU - Pal, Amit
AU - Squitti, Rosanna
AU - Goswami, Kalyan
AU - Pradhan, Keerti Bhusan
AU - Rustagi, Sarvesh
AU - Hermis, Alaa Hamza
AU - Barboza, Joshuan J.
AU - Rodriguez-Morales, Alfonso J.
AU - Sah, Ranjit
AU - Padhi, Bijaya K.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/6
Y1 - 2023/6
N2 - Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68–22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.
AB - Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68–22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.
KW - cutaneous
KW - infection
KW - meta-analysis
KW - monkeypox
KW - skin lesion
KW - skin swab
UR - http://www.scopus.com/inward/record.url?scp=85163960863&partnerID=8YFLogxK
U2 - 10.3390/v15061386
DO - 10.3390/v15061386
M3 - Artículo de revisión
C2 - 37376686
AN - SCOPUS:85163960863
SN - 1999-4915
VL - 15
JO - Viruses
JF - Viruses
IS - 6
M1 - 1386
ER -
