TY - JOUR
T1 - Understanding Risk Factors for Poor Outcomes in a Multiethnic Longitudinal Cohort
T2 - The LUMINA (Lupus in Minorities: Nature vs. Nurture) Experience (LUMINA LXXXII)
AU - González, Luis Alonso
AU - Pons-Estel, Guillermo J.
AU - Toloza, Sergio M.A.
AU - Ugarte-Gil, Manuel Francisco
AU - Alarcón, Graciela S.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2
Y1 - 2021/2
N2 - The Lupus in Minorities: Nature Vs Nurture (LUMINA) cohort has placed Hispanics on the lupus map in the United States. Texan Hispanic and African American patients experience, overall, worse outcomes than the Caucasian and Puerto Rican Hispanic patients. The genetic component of ethnicity is important early in the disease course whereas socioeconomic factors become more important subsequently. The role of hydroxychloroquine in preventing damage accrual and reducing mortality in lupus patients is a major contribution of LUMINA.
AB - The Lupus in Minorities: Nature Vs Nurture (LUMINA) cohort has placed Hispanics on the lupus map in the United States. Texan Hispanic and African American patients experience, overall, worse outcomes than the Caucasian and Puerto Rican Hispanic patients. The genetic component of ethnicity is important early in the disease course whereas socioeconomic factors become more important subsequently. The role of hydroxychloroquine in preventing damage accrual and reducing mortality in lupus patients is a major contribution of LUMINA.
KW - Disease activity
KW - Disparities
KW - Ethnicity
KW - LUMINA
KW - Lupus
KW - Mortality
KW - Quality of life
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85094809267&partnerID=8YFLogxK
U2 - 10.1016/j.rdc.2020.09.002
DO - 10.1016/j.rdc.2020.09.002
M3 - Artículo de revisión
C2 - 34042054
AN - SCOPUS:85094809267
SN - 0889-857X
VL - 47
SP - 55
EP - 64
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 1
ER -