TY - JOUR
T1 - Treat to target in systemic lupus erythematosus
T2 - a commentary
AU - Ugarte-Gil, Manuel F.
AU - Burgos, Paula I.
AU - Alarcón, Graciela S.
N1 - Publisher Copyright:
© 2016, International League of Associations for Rheumatology (ILAR).
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease activity, improve health-related quality of life, and reduce morbidity and mortality. Remission would be the main target, but a low disease activity state (LDAS) could be an acceptable alternative. However, due to SLE protean manifestations, the operational definitions of both remission and LDAS are still in progress. The definitions of these targets, remission and LDAS, should include a validated disease activity index, the treatments allowed, and the minimum length of time the target should be maintained. Furthermore, achieving these targets should result in better disease outcomes such as reducing damage accrual. This review addresses the current state regarding these possible targets in SLE and the impact of achieving them in intermediate and long-term outcomes of this disease.
AB - Treat to target (T2T) strategies have proved to be useful in several chronic disorders, including Rheumatoid Arthritis. In systemic lupus erythematosus (SLE), T2T strategy has been proposed in order to control disease activity, improve health-related quality of life, and reduce morbidity and mortality. Remission would be the main target, but a low disease activity state (LDAS) could be an acceptable alternative. However, due to SLE protean manifestations, the operational definitions of both remission and LDAS are still in progress. The definitions of these targets, remission and LDAS, should include a validated disease activity index, the treatments allowed, and the minimum length of time the target should be maintained. Furthermore, achieving these targets should result in better disease outcomes such as reducing damage accrual. This review addresses the current state regarding these possible targets in SLE and the impact of achieving them in intermediate and long-term outcomes of this disease.
KW - Outcome
KW - Remission
KW - Systemic lupus erythematosus
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84978173313&partnerID=8YFLogxK
U2 - 10.1007/s10067-016-3346-2
DO - 10.1007/s10067-016-3346-2
M3 - Artículo
C2 - 27406378
AN - SCOPUS:84978173313
SN - 0770-3198
VL - 35
SP - 1903
EP - 1907
JO - Clinical Rheumatology
JF - Clinical Rheumatology
IS - 8
ER -