Transferable mechanisms of quinolone resistance

Joaquim Ruiz, Maria J. Pons, Cláudia Gomes

Research output: Contribution to journalShort surveypeer-review

77 Scopus citations

Abstract

Quinolones were introduced into clinical practice in the late 1960s. Although quinolone resistance was described early, no transferable mechanism of quinolone resistance (TMQR) was confirmed until 1998. To date, five different TMQRs have been described in the literature, including target protection (Qnr), quinolone modification (AAC(6′)-Ib-cr), plasmid-encoded efflux systems (e.g. QepA or OqxAB, amongst others), effect on bacterial growth rates and natural transformation. Although TMQRs usually only result in a slight increase in the minimum inhibitory concentrations of quinolones, they possess an additive effect and may facilitate the acquisition of full quinolone resistance. The emergence of new related genes may continue in the next years.

Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalInternational Journal of Antimicrobial Agents
Volume40
Issue number3
DOIs
StatePublished - Sep 2012

Keywords

  • AAC(6′)-Ib-cr
  • Natural transformation
  • OqxAB
  • Qep
  • Qnr
  • Quinolone resistance

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