TY - JOUR
T1 - TOXOPLASMOSIS CONGÉNITA CON ENFERMEDAD NEUROLÓGICA SEVERA EN UN HOSPITAL DE REFERENCIA DEL PERÚ
AU - Maquera-Afaray, Julio
AU - Luna-Vilchez, Medalit
AU - Salazar-Mesones, Blanca
AU - Chiara-Chilet, Christian
AU - Cordero-Campos, Alexander
AU - López, José W.
N1 - Publisher Copyright:
© 2022, Instituto Nacional de Salud. All rights reserved.
PY - 2022
Y1 - 2022
N2 - The aim of this study was to describe the epidemiological, clinical, and therapeutic characteristics of patients diagnosed with congenital toxoplasmosis (CT) with severe neurological disease. We reviewed the medical records of patients under 1 year of age with positive IgM test for Toxoplasma gondii and brain, eye, and/or hearing involvement. This study was carried out at the Instituto Nacional de Salud del Niño San Borja (INSNSB), Lima, Peru. Twenty-one patients diagnosed with CT were evaluated; 57.1% were female, and the median age at diagnosis was 3.1 months (IQR: 1.7-7.3). The main central nervous system manifestations were hydrocephalus (76.2%), intracranial calcifications (52.4%), microcephaly (42.9%), and convulsions (25.6%); the most frequent ocular manifestation was chorioretinitis (38.1%). In conclusion, 64% of CT cases had one or more manifestations of severe neurological disease.
AB - The aim of this study was to describe the epidemiological, clinical, and therapeutic characteristics of patients diagnosed with congenital toxoplasmosis (CT) with severe neurological disease. We reviewed the medical records of patients under 1 year of age with positive IgM test for Toxoplasma gondii and brain, eye, and/or hearing involvement. This study was carried out at the Instituto Nacional de Salud del Niño San Borja (INSNSB), Lima, Peru. Twenty-one patients diagnosed with CT were evaluated; 57.1% were female, and the median age at diagnosis was 3.1 months (IQR: 1.7-7.3). The main central nervous system manifestations were hydrocephalus (76.2%), intracranial calcifications (52.4%), microcephaly (42.9%), and convulsions (25.6%); the most frequent ocular manifestation was chorioretinitis (38.1%). In conclusion, 64% of CT cases had one or more manifestations of severe neurological disease.
KW - Central Diabetes Insipidus (Source: MeSH NLM)
KW - Chorioretinitis
KW - Congenital Toxoplasmosis
KW - Hydrocephalus
KW - Microcephaly
UR - http://www.scopus.com/inward/record.url?scp=85137800052&partnerID=8YFLogxK
U2 - 10.17843/rpmesp.2022.392.10897
DO - 10.17843/rpmesp.2022.392.10897
M3 - Artículo
AN - SCOPUS:85137800052
SN - 1726-4634
VL - 39
SP - 208
EP - 213
JO - Revista Peruana de Medicina Experimental y Salud Publica
JF - Revista Peruana de Medicina Experimental y Salud Publica
IS - 2
ER -