The SLICC-FI Predicts Damage Accrual in SLE Patients. Data From the Almenara Lupus Cohort

Claudia Elera-Fitzcarrald, Rocío V. Gamboa-Cárdenas, Cristina Reatégui-Sokolova, Victor Pimentel-Quiroz, Zoila Rodriguez-Bellido, César A. Pastor-Asurza, Risto Perich-Campos, Graciela S. Alarcón, Manuel F. Ugarte-Gil

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: To evaluate the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as a predictor of damage accrual in a primarily Mestizo SLE patient cohort. Methods: Patients from a single-center prevalent cohort were included. Damage accrual was defined as the increase in the SLICC/American College of Rheumatology (ACR) damage index (SDI) scores between the baseline and the last visits. The SLICC-FI was measured at baseline. Univariable and multivariable Cox regression models were performed to determine the association between the baseline SLICC-FI (per 0.05 increase) and the increase in the SDI, adjusted for possible confounders. Alternative analyses using negative binomial regression models including the difference between the last and the first SDI as outcome were performed. Results: Of the 265 patients included, 248 (93.6%) were female with mean (SD) age of 35.1 (13.6) years at diagnosis. At baseline, mean (SD) SLE disease duration was 7.3 (6.5) years, SDI was 1.0 (1.2) and the SLICC-FI was 0.22 (0.05). After a mean (SD) of 5.2 (2.2) years of follow-up, the SDI increased in 126 (47.5%) patients, and the final mean (SD) SDI score was 1.7 (1.7). Higher SLICC-FI scores at baseline predicted greater damage accrual in the univariable analysis [Hazard Ratio (HR) =1.38, (CI95% 1.16–1.65); p < 0.001] and in the multivariable model, after adjustment for possible confounders [HR = 1.30 (CI95% 1.02–1.66); p = 0.033]. Conclusion: SLICC-FI predicts the occurrence of damage accrual in a prevalent SLE Latin-American cohort with short or long disease duration, supporting the relevance of this index in the evaluation of SLE patients.

Original languageEnglish
Pages (from-to)1666-1670
Number of pages5
Issue number13
StatePublished - Nov 2022


  • damage
  • frailty
  • systemic erythematosus lupus
  • systemic lupus international collaborating clinics frailty index


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