TY - JOUR
T1 - The impact of outdoor pollution and extreme temperatures on asthma-related outcomes
T2 - A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
AU - Agache, Ioana
AU - Canelo-Aybar, Carlos
AU - Annesi-Maesano, Isabella
AU - Cecchi, Lorenzo
AU - Rigau, David
AU - Rodríguez-Tanta, L. Yesenia
AU - Nieto-Gutierrez, Wendy
AU - Song, Yang
AU - Cantero-Fortiz, Yahveth
AU - Roqué, Marta
AU - Vasquez, Juan Carlos
AU - Sola, Ivan
AU - Biagioni, Benedetta
AU - Chung, Fan
AU - D'Amato, Gennaro
AU - Damialis, Athanasios
AU - del Giacco, Stefano
AU - Vecillas, Leticia de las
AU - Dominguez-Ortega, Javier
AU - Galàn, Carmen
AU - Gilles, Stefanie
AU - Giovannini, Mattia
AU - Holgate, Stephen
AU - Jeebhay, Mohamed
AU - Nadeau, Kari
AU - Papadopoulos, Nikolaos
AU - Quirce, Santiago
AU - Sastre, Joaquin
AU - Traidl-Hoffmann, Claudia
AU - Walusiak-Skorupa, Jolanta
AU - Sousa-Pinto, Bernardo
AU - Alonso-Coello, Pablo
AU - Salazar, Josefina
AU - Jutel, Marek
AU - Akdis, Cezmi A.
N1 - Publisher Copyright:
© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2024/7
Y1 - 2024/7
N2 - Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systematic review (SR) evaluated the impact on asthma-related outcomes of short-term exposure to outdoor air pollutants (PM2.5, PM10, NO2, SO2, O3, and CO), heavy traffic, outdoor pesticides, and extreme temperatures. Additionally, the SR evaluated the impact of the efficacy of interventions reducing outdoor pollutants. The risk of bias was assessed using ROBINS-E tools and the certainty of the evidence by using GRADE. Short-term exposure to PM2.5, PM10, and NO2 probably increases the risk of asthma-related hospital admissions (HA) and emergency department (ED) visits (moderate certainty evidence). Exposure to heavy traffic may increase HA and deteriorate asthma control (low certainty evidence). Interventions reducing outdoor pollutants may reduce asthma exacerbations (low to very low certainty evidence). Exposure to fumigants may increase the risk of new-onset asthma in agricultural workers, while exposure to 1,3-dichloropropene may increase the risk of asthma-related ED visits (low certainty evidence). Heatwaves and cold spells may increase the risk of asthma-related ED visits and HA and asthma mortality (low certainty evidence).
AB - Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systematic review (SR) evaluated the impact on asthma-related outcomes of short-term exposure to outdoor air pollutants (PM2.5, PM10, NO2, SO2, O3, and CO), heavy traffic, outdoor pesticides, and extreme temperatures. Additionally, the SR evaluated the impact of the efficacy of interventions reducing outdoor pollutants. The risk of bias was assessed using ROBINS-E tools and the certainty of the evidence by using GRADE. Short-term exposure to PM2.5, PM10, and NO2 probably increases the risk of asthma-related hospital admissions (HA) and emergency department (ED) visits (moderate certainty evidence). Exposure to heavy traffic may increase HA and deteriorate asthma control (low certainty evidence). Interventions reducing outdoor pollutants may reduce asthma exacerbations (low to very low certainty evidence). Exposure to fumigants may increase the risk of new-onset asthma in agricultural workers, while exposure to 1,3-dichloropropene may increase the risk of asthma-related ED visits (low certainty evidence). Heatwaves and cold spells may increase the risk of asthma-related ED visits and HA and asthma mortality (low certainty evidence).
KW - GRADE
KW - asthma
KW - extreme temperatures
KW - outdoor pollution
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85184248564&partnerID=8YFLogxK
U2 - 10.1111/all.16041
DO - 10.1111/all.16041
M3 - Artículo de revisión
C2 - 38311978
AN - SCOPUS:85184248564
SN - 0105-4538
VL - 79
SP - 1725
EP - 1760
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 7
ER -