TY - JOUR
T1 - Synergistic anti-inflammatory effect of NSAIDs plus B vitamins administered pre and postoperatively in third molar surgery
T2 - randomized clinical trial
AU - Pérez-Jimenez, Vanessa Roxana
AU - Chumpitaz-Cerrate, Victor Manuel
AU - Chávez-Rimache, Lesly Karem
AU - Moreno-Villalobos, David Erik
AU - Rodríguez-Flores, Arturo Alberto
AU - Franco-Quino, Cesar Ivanovish
AU - Erazo-Paredes, Carlos Humberto
N1 - Publisher Copyright:
© 2022, Universidade Estadual Paulista, Institute of Science and Technology of Sao Jose dos Campos. All rights reserved.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Objective: The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods: Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student’s t-test was performed for independent samples. Results: In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion: In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups.
AB - Objective: The aim of the present study was to evaluate the synergistic anti-inflammatory effect of Non-steroidal anti-inflammatory drugs (NSAIDs) plus B vitamins administered pre and postoperatively in surgeries of impacted mandibular third molars. Material and Methods: Double-blind randomized clinical trial, sixty-six patients participated and were randomized into 2 groups. The control group was administered meloxicam 15 mg intramuscularly plus placebo orally and to the experimental group, meloxicam 15 mg intramuscularly plus vitamins B [B1, B6, and B12] orally; both treatments were administered preoperatively. The anti-inflammatory effect was evaluated by pain intensity, facial swelling (facial contour measurements), and mouth opening (distance between the upper and lower incisors) during the post-surgical phase. Student’s t-test was performed for independent samples. Results: In all the evaluated times (1 hour, 6 hours, 12 hours, 24 hours, 2 days, and 3 days after the end of the surgery) the experimental group presented a significantly lower intensity of pain compared to the control group (p<0.05). The highest pain intensity was recorded at 6 hours (17.7 ± 9.1 mm in the experimental group and 34.5 ± 21.3 mm in the control group). Swelling and mouth opening were similar in both groups, at all times evaluated (p>0.05). Conclusion: In the present study, the administration of NSAIDs plus B vitamins (B1, B6, B12) produced lower intensity of pain compared to the administration of only NSAIDs. Nevertheless, swelling and mouth opening were similar in all evaluations for both study groups.
KW - Inflammation
KW - Meloxicam
KW - Molar, third
KW - Pain
KW - Vitamin B complex
UR - http://www.scopus.com/inward/record.url?scp=85139387643&partnerID=8YFLogxK
U2 - 10.4322/bds.2022.e3441
DO - 10.4322/bds.2022.e3441
M3 - Artículo
AN - SCOPUS:85139387643
SN - 2178-6011
VL - 25
JO - Brazilian Dental Science
JF - Brazilian Dental Science
IS - 4
M1 - e3441
ER -