Resistencia a antimicrobianos betalactámicos en Salmonella enterica serovar infantis aisladas en la región nordeste de Argentina

Luis Antonio Merino; José Mario Alonso; Margarita Mariá Navia; Joaquiń Ruiź; Josep Sierra; Jordi Vila

Resistencia a antimicrobianos betalactámicos en Salmonella enterica serovar infantis aisladas en la región nordeste de Argentina

Translated title of the contribution: Resistance to beta-lactamase antimicrobials in Salmonella enterica serovar infantis isolated in the northeastern region of Argentina

Luis Antonio Merino, José Mario Alonso, Margarita Mariá Navia, Joaquiń Ruiź, Josep Sierra, Jordi Vila

Medicina humana

Research output: Contribution to journal › Article › peer-review

Abstract

In order to study the resistance to â-lactam antimicrobials and the mechanisms involved in Salmonella infantis strains in the Northeast of Argentina, twenty nine strains isolated from faeces between February and December 1998 were studied. All strains were resistant to ampicillin, cephalothin, and ampicillin/clavulanic acid but susceptible to cefoxitin. Ten strains were resistant to cefotaxime. A â-lactamase compatible with TEM-1-like were found in all isolates. An additional CTX-M-2-like â-lactamase was detected only in the cefotaxime-resistant strains. Mating experiments confirmed that this resistance genes were located on a conjugative plasmid harbouring one class I integron. Characterisation of ESBL-type by molecular methods could conduce to a better understanding of the evolution and spreading of the â-lactamases family and can alert about the need to adequate the use of antimicrobials in humans as in animal applications.

Translated title of the contribution	Resistance to beta-lactamase antimicrobials in Salmonella enterica serovar infantis isolated in the northeastern region of Argentina
Original language	Spanish
Journal	Enfermedades Infecciosas y Microbiologia
Volume	25
Issue number	3
State	Published - Jul 2005

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title = "Resistencia a antimicrobianos betalact{\'a}micos en Salmonella enterica serovar infantis aisladas en la regi{\'o}n nordeste de Argentina",

abstract = "In order to study the resistance to {\^a}-lactam antimicrobials and the mechanisms involved in Salmonella infantis strains in the Northeast of Argentina, twenty nine strains isolated from faeces between February and December 1998 were studied. All strains were resistant to ampicillin, cephalothin, and ampicillin/clavulanic acid but susceptible to cefoxitin. Ten strains were resistant to cefotaxime. A {\^a}-lactamase compatible with TEM-1-like were found in all isolates. An additional CTX-M-2-like {\^a}-lactamase was detected only in the cefotaxime-resistant strains. Mating experiments confirmed that this resistance genes were located on a conjugative plasmid harbouring one class I integron. Characterisation of ESBL-type by molecular methods could conduce to a better understanding of the evolution and spreading of the {\^a}-lactamases family and can alert about the need to adequate the use of antimicrobials in humans as in animal applications.",

keywords = "Antimicrobial resistance of Argentina, Beta-lactamases, Salmonella infantis",

author = "Merino, {Luis Antonio} and Alonso, {Jos{\'e} Mario} and Navia, {Margarita Mari{\'a}} and Joaqui{\'n} Rui{\'z} and Josep Sierra and Jordi Vila",

year = "2005",

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journal = "Enfermedades Infecciosas y Microbiologia",

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AU - Merino, Luis Antonio

AU - Alonso, José Mario

AU - Navia, Margarita Mariá

AU - Ruiź, Joaquiń

AU - Sierra, Josep

AU - Vila, Jordi

PY - 2005/7

Y1 - 2005/7

N2 - In order to study the resistance to â-lactam antimicrobials and the mechanisms involved in Salmonella infantis strains in the Northeast of Argentina, twenty nine strains isolated from faeces between February and December 1998 were studied. All strains were resistant to ampicillin, cephalothin, and ampicillin/clavulanic acid but susceptible to cefoxitin. Ten strains were resistant to cefotaxime. A â-lactamase compatible with TEM-1-like were found in all isolates. An additional CTX-M-2-like â-lactamase was detected only in the cefotaxime-resistant strains. Mating experiments confirmed that this resistance genes were located on a conjugative plasmid harbouring one class I integron. Characterisation of ESBL-type by molecular methods could conduce to a better understanding of the evolution and spreading of the â-lactamases family and can alert about the need to adequate the use of antimicrobials in humans as in animal applications.

AB - In order to study the resistance to â-lactam antimicrobials and the mechanisms involved in Salmonella infantis strains in the Northeast of Argentina, twenty nine strains isolated from faeces between February and December 1998 were studied. All strains were resistant to ampicillin, cephalothin, and ampicillin/clavulanic acid but susceptible to cefoxitin. Ten strains were resistant to cefotaxime. A â-lactamase compatible with TEM-1-like were found in all isolates. An additional CTX-M-2-like â-lactamase was detected only in the cefotaxime-resistant strains. Mating experiments confirmed that this resistance genes were located on a conjugative plasmid harbouring one class I integron. Characterisation of ESBL-type by molecular methods could conduce to a better understanding of the evolution and spreading of the â-lactamases family and can alert about the need to adequate the use of antimicrobials in humans as in animal applications.

KW - Antimicrobial resistance of Argentina

KW - Beta-lactamases

KW - Salmonella infantis

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M3 - Artículo

AN - SCOPUS:84855857574

SN - 1405-0994

VL - 25

JO - Enfermedades Infecciosas y Microbiologia

JF - Enfermedades Infecciosas y Microbiologia

IS - 3

ER -

Resistencia a antimicrobianos betalactámicos en Salmonella enterica serovar infantis aisladas en la región nordeste de Argentina

Abstract

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