TY - JOUR
T1 - Resección microquirúrgica de glioblastoma guiada con fluoresceína intraoperatoria
T2 - Evaluación retrospectiva
AU - García-Corrochano, Pamela
AU - Castañeda, Carlos Altamirano
AU - Orrego, Enrique
AU - Deza, Pedro
AU - Heinicke, Hugo
AU - Casavilca, Sandro
AU - Castillo, Miluska
AU - Cortez, Karen
AU - Belmar, Carolina
AU - Dolores, Ketty
AU - Flores, Claudio
AU - Ojeda, Luis
N1 - Publisher Copyright:
© 2015, Instituto Nacional de Salud. All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p<0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p<0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival.
AB - Objectives. To evaluate the influence of the use of sodium fluorescein (FLS-Na) in surgery of glioblastoma (GB) on the degree of tumor resection and survival in patients treated at the National Institute of Neoplastic Diseases. Materials and methods. A total of 238 cases of GB treated between 2008 and 2013 were reviewed and 150 cases of GB who underwent surgical resection with clinicopathological information and adequate follow-up were selected. Results. The mean age was 51 years, 58.7% of the cases presented a Karnofsky score of at least 90. FLS-Na was administered in 80 cases (53.3%) and a subtotal and total resection was obtained in 69 (46%) and 81 (54%) cases, respectively. The group that received FLS-Na obtained higher rates of total resection than the group operated with white light alone (77.5 vs 27.1%, p<0.001). The median overall survival (OS) was higher in the group subject to total compared to subtotal resection (17 vs 7 months, p<0.001). The median OS in those who received FLS-Na was higher than in those who did not (15.0 vs 8 months, p=0.003). Other factors affecting OS were age (p=0.002), the Karnofsky score (p=0.052) and radiation therapy (p=0.016) and chemotherapy (p=0.011). Conclusions. The microsurgical technique with administration of FLS-Na was associated with an increase in the rate of total resection and survival.
KW - Fluorescein
KW - Glioblastoma
KW - Microsurgery
KW - Survival analysis (source: MeSH NLM)
UR - http://www.scopus.com/inward/record.url?scp=84949959855&partnerID=8YFLogxK
U2 - 10.17843/rpmesp.2015.323.1676
DO - 10.17843/rpmesp.2015.323.1676
M3 - Artículo
C2 - 26580928
AN - SCOPUS:84949959855
SN - 1726-4634
VL - 32
SP - 471
EP - 478
JO - Revista Peruana de Medicina Experimental y Salud Publica
JF - Revista Peruana de Medicina Experimental y Salud Publica
IS - 3
ER -