Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii

Jordi Vila, Joaquim Ruiz, Pilar Goñi, Teresa Jimenez De Anta

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151 Scopus citations

Abstract

Mutations in the parC gene, which encodes a subunit of topoisomerase IV, were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone-resistance-determining region of the parC gene from A. baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of ≤ 32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys. These results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A. baumannii highly resistant to quinolones.

Original languageEnglish
Pages (from-to)757-762
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume39
Issue number6
DOIs
StatePublished - 1997

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