Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Kavya G. Sundar, Lanbo Z. Yang, Mary C. Cambou, Ivana R.S. Varella, Marineide G. Melo, Eddy R. Segura, Ângela P. Ziegler, Breno R. Santos, Karin Nielsen-Saines

Research output: Contribution to journalArticlepeer-review

Abstract

From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

Original languageEnglish
Article number10.1097/INF.0000000000004562
JournalPediatric Infectious Disease Journal
DOIs
StateAccepted/In press - 2024

Keywords

  • HIV in pregnancy
  • HIV vertical transmission
  • adverse infant outcomes
  • antiretroviral therapy in pregnancy
  • maternal HIV seroconversion

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