Polymorphism in CRHR1 gene affects the IL-1β levels in suicidal attempters

Clarissa R. Bastos, Marta Gazal, Luciana de A. Quevedo, Joice Luisa Costa, Carolina D. Wiener, Karen Jansen, Christian Loret de Mola, Jean P. Oses, Luciano D.M. Souza, Luiz Valmor Portela, Ricardo T. Pinheiro, Ricardo A. da Silva, Diogo R. Lara, Gabriele Ghisleni

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Approximately one million people commit suicide every year, being suicide attempts and ideation even more common. Changes in stress response and activation of the immune system have been associated with suicide risk. Here we investigated the interaction between immune system and HPA axis alterations in the suicide risk, looking for the influence of rs110402 CRHR1 SNP in the IL-1β levels according to suicide ideation and attempt. This study evaluated 171 subjects of which 15 had suicidal ideation, 20 had suicide attempt and 136 were controls. Genotyping was performed by real-time PCR and IL-1β levels were measured by ELISA. Our data showed that for each point increase in IL-1β levels the risk of suicide attempt increased 5% [relative risk = 1.05 (95% CI: 1.0–1.10)]. After sample stratification by rs110402 SNP genotypes, we observed that in subjects carrying the A allele the risk raised to 15% [relative risk = 1.15 (95% CI: 1.03–1.28)], suggesting an apparent effect modification. Thus, this study showed that alterations in CRHR1 gene were associated with higher levels of IL-1β, and increased risk for suicide, reinforcing the importance of multifactorial interactions of biological markers for psychiatric disorders.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalJournal of Psychiatric Research
StatePublished - 1 Mar 2017
Externally publishedYes


  • CRHR1
  • HPA axis
  • Inflammation
  • Interleukin-1β
  • Polymorphism
  • Suicide risk


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