Pleuropericardial Compromise Associated With Graves’ Disease: A Systematic Review

Jose Luis Paz-Ibarra, Diego Enrique Sueldo-Espinoza, Ronald Vicente Concha-Tamo, Vladimir Zamame-Ramirez, Victor Velasquez-Rimachi, Marcio Jose Concepcion-Zavaleta

Research output: Contribution to journalReview articlepeer-review


Graves’ disease (GD) is the main cause of hyperthyroidism. Cardiovascular complications of GD may have a delayed onset, accompanied by pericardial and pleural inflammation or inflammatory effusions. Pleuro-pericardial compromise (PPC) associated with GD is a rare disorder. It is postulated that the pathophysiology may involve an interaction between antithyroid antibodies and pericardium. Currently, there is no guideline for the treatment of GD-induced serositis. We conducted a systematic review to compare similar PPCs in GD reports. This article aimed to summarize the information to understand physiopathology and propose preliminary management. A total of 14 articles describing 16 cases of serositis induced by GD were selected. The characteristics of the pleu-ral and pericardial fluid express the inflammatory nature of GD and fa-cilitate the diagnosis. Imaging methods, mainly ultrasound (US), chest X-ray, and computed tomography (CT), contribute to the diagnosis of PPC. Treatment of GD could be the cornerstone in the management of this entity, adding radioactive iodine as a definitive therapy if the patient does not reach a euthyroid state with antithyroid drugs.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Endocrinology and Metabolism
Issue number1
StatePublished - Feb 2022


  • Antithyroid agents
  • Graves’ disease
  • Pericarditis
  • Pleurisy


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