TY - JOUR
T1 - Phylodynamic analysis in the understanding of the current COVID-19 pandemic and its utility in vaccine and antiviral design and assessment
AU - Cardona-Ospina, Jaime A.
AU - Rojas-Gallardo, Diana M.
AU - Garzón-Castaño, Sandra C.
AU - Jiménez-Posada, Erika V.
AU - Rodríguez-Morales, Alfonso J.
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Over the last decades, the use of phylogenetic methods in the study of emerging infectious diseases has gained considerable traction in public health. Particularly, the integration of phylogenetic analyses with the understanding of the pathogen dynamics at the population level has provided powerful tools for epidemiological surveillance systems. In the same way, the development of statistical methods and theory, as well as improvement of computational efficiency for evolutionary analysis, has expanded the use of these tools for vaccine and antiviral development. Today with the Coronavirus Disease 2019 (COVID-19), this seems to be critical. In this article, we discuss how the application of phylodynamic analysis can improve the understanding of current pandemic dynamics as well as the design, selection, and evaluation of vaccine candidates and antivirals.
AB - Over the last decades, the use of phylogenetic methods in the study of emerging infectious diseases has gained considerable traction in public health. Particularly, the integration of phylogenetic analyses with the understanding of the pathogen dynamics at the population level has provided powerful tools for epidemiological surveillance systems. In the same way, the development of statistical methods and theory, as well as improvement of computational efficiency for evolutionary analysis, has expanded the use of these tools for vaccine and antiviral development. Today with the Coronavirus Disease 2019 (COVID-19), this seems to be critical. In this article, we discuss how the application of phylodynamic analysis can improve the understanding of current pandemic dynamics as well as the design, selection, and evaluation of vaccine candidates and antivirals.
KW - COVID-19
KW - SARS-CoV-2
KW - antivirals
KW - phylodynamic
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85101134521&partnerID=8YFLogxK
U2 - 10.1080/21645515.2021.1880254
DO - 10.1080/21645515.2021.1880254
M3 - Artículo de revisión
C2 - 33606594
AN - SCOPUS:85101134521
SN - 2164-5515
VL - 17
SP - 2437
EP - 2444
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
IS - 8
ER -
