TY - JOUR
T1 - Obesity and ADHD
T2 - Exploring the role of body composition, BMI polygenic risk score, and reward system genes
AU - Martins-Silva, Thais
AU - Vaz, Juliana dos Santos
AU - Genro, Júlia Pasqualini
AU - Hutz, Mara Helena
AU - Loret de Mola, Christian
AU - Mota, Nina Roth
AU - Oliveira, Isabel
AU - Gigante, Denise Petrucci
AU - Pinheiro, Ricardo Tavares
AU - Vitola, Eduardo
AU - Grevet, Eugenio
AU - Horta, Bernardo L.
AU - Rohde, Luis Augusto
AU - Tovo-Rodrigues, Luciana
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/4
Y1 - 2021/4
N2 - The association between obesity and attention-deficit hyperactivity disorder (ADHD) has been extensively reported in the literature. However, the potential mechanisms underlying this association are not completely understood. This study aimed to evaluate the association between body composition and ADHD and explore the possible genetic mechanisms involved. We used data from the 1982 Pelotas (Brazil) Birth Cohort at age 30-year follow-up (N = 3630). We first used logistic regression analysis to test whether body mass index (BMI), fat mass (FM), and fat-free mass (FFM) were associated with ADHD. We further tested the association between BMI polygenic risk score (BMI-PRS) and ADHD and the role of the genes upregulated in the reward system using a gene-set association approach. BMI (odds ratio [OR] = 1.05; 95% confidence interval [CI], 1.00–1.09; p = 0.038) and FM (OR = 1.04; 95% CI, 1.00–1.07; p = 0.043) were associated with ADHD. The BMI-PRS was associated with ADHD (using p-value threshold (PT) = 0.4; OR = 1.65; 95% CI, 1.02–2.65) at a nominal level. In gene-set analysis, the reward system genes were associated with BMI in subjects with a high BMI-PRS score, considering PT = 0.4 (p = 0.014). The results suggest that BMI genetic components, especially those genes related to the reward system, may be involved in this association.
AB - The association between obesity and attention-deficit hyperactivity disorder (ADHD) has been extensively reported in the literature. However, the potential mechanisms underlying this association are not completely understood. This study aimed to evaluate the association between body composition and ADHD and explore the possible genetic mechanisms involved. We used data from the 1982 Pelotas (Brazil) Birth Cohort at age 30-year follow-up (N = 3630). We first used logistic regression analysis to test whether body mass index (BMI), fat mass (FM), and fat-free mass (FFM) were associated with ADHD. We further tested the association between BMI polygenic risk score (BMI-PRS) and ADHD and the role of the genes upregulated in the reward system using a gene-set association approach. BMI (odds ratio [OR] = 1.05; 95% confidence interval [CI], 1.00–1.09; p = 0.038) and FM (OR = 1.04; 95% CI, 1.00–1.07; p = 0.043) were associated with ADHD. The BMI-PRS was associated with ADHD (using p-value threshold (PT) = 0.4; OR = 1.65; 95% CI, 1.02–2.65) at a nominal level. In gene-set analysis, the reward system genes were associated with BMI in subjects with a high BMI-PRS score, considering PT = 0.4 (p = 0.014). The results suggest that BMI genetic components, especially those genes related to the reward system, may be involved in this association.
KW - Attention-deficit/hyperactivity disorder
KW - Body composition
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=85094600989&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2020.10.026
DO - 10.1016/j.jpsychires.2020.10.026
M3 - Artículo
C2 - 33127071
AN - SCOPUS:85094600989
SN - 0022-3956
VL - 136
SP - 529
EP - 536
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -
