Novel contiguous gene deletion in peruvian girl with Trichothiodystrophy type 4 and glutaric aciduria type 3

Jorge La Serna-Infantes, Miguel Chávez Pastor, Milana Trubnykova, Félix Chavesta Velásquez, Flor Vásquez Sotomayor, Hugo Abarca Barriga

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Trichothiodystrophy type 4 is a rare autosomal recessive and ectodermal disorder, characterized by dry, brittle, sparse and sulfur-deficient hair and other features like intellectual disability, ichthyotic skin and short stature, caused by a homozygous mutation in MPLKIP gene. Glutaric aciduria type 3 is caused by a homozygous mutation in SUGCT gene with no distinctive phenotype. Both genes are localized on chromosome 7 (7p14). We report an 8-year-old female with short stature, microcephaly, development delay, intellectual disability and hair characterized for dark, short, coarse, sparse and brittle associated to classical trichorrhexis microscopy pattern. Chromosome microarray analysis showed a 125 kb homozygous pathogenic deletion, which includes genes MPLKIP and SUGCT, not described before. This is the first case described in Peru of a novel contiguous gene deletion of Trichothiodystrophy type 4 and Glutaric aciduria type 3 performed by chromosome microarray analysis, highlighting the contribution and importance of molecular technologies on diagnosis of rare genetic conditions.

Original languageEnglish
Pages (from-to)388-392
Number of pages5
JournalEuropean Journal of Medical Genetics
Volume61
Issue number7
DOIs
StatePublished - Jul 2018

Keywords

  • Chromosome microarray analysis
  • Glutaric aciduria 3
  • Glutaryl-CoA oxidase deficiency
  • MLKIP
  • Nonphotosensitive
  • SUGCT
  • Trichothiodystrophy

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