Nitrofuran resistance in Salmonella enterica isolated from meat for human consumption

Sandra Martínez-Puchol, María J. Pons, Lidia Ruiz-Roldán, Laura Laureano-Adame, Alfredo Corujo, Theresa J. Ochoa, Joaquim Ruiz

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3 Scopus citations


The mechanisms of resistance to nitrofurans from 18 meat samples with Salmonella enterica (chicken: 15; beef: 2; pork: 1) collected in Lima (Peru) were analyzed. The isolates were serotyped and the susceptibility levels to furazolidone and nitrofurantoin [with and without the efflux pump inhibitor Phenyl-Arginine-β-naphthylamide (PAβN)], the presence of mutations in the snrA and cnr genes and the transferability of resistance by conjugation were established. Fifteen samples with S. infantis (13 from chicken samples), 2 with S. enteritidis and 1 with S. anatum were identified. All isolates except the S. anatum were resistant to both nitrofurans showing MICs (minimum inhibitory concentration) of furazolidone and nitrofurantoin of 32-64 μg/mL and 128-256 μg/mL, respectively. The addition of PAßN had no effect on the MIC levels. All nitrofuran-resistant isolates showed amino acid codon alterations at both snrA and cnr (S. infantis: snrA STOP-151; cnr STOP-137; S. enteritidis: snrA STOP-180; cnr STOP-179). No transferable mechanisms of nitrofuran resistance were detected.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalRevista Peruana de Medicina Experimental y Salud Publica
Issue number1
StatePublished - 2020


  • Drug resistance
  • Furazolidone
  • Salmonella (source: MeSH NLM)


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