Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis

Juan P. Horcajada; Jordi Vila; Antonio Moreno-Martínez; Joaquim Ruiz; Jose Antonio Martínez; Miquel Sánchez; Eladio Soriano; Josep Mensa

doi:10.1093/jac/49.1.55

Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis

Juan P. Horcajada, Jordi Vila, Antonio Moreno-Martínez, Joaquim Ruiz, Jose Antonio Martínez, Miquel Sánchez, Eladio Soriano, Josep Mensa

Medicina humana

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Abstract

The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.

Original language	English
Pages (from-to)	55-59
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	49
Issue number	1
DOIs	https://doi.org/10.1093/jac/49.1.55
State	Published - 2002

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Horcajada, J. P., Vila, J., Moreno-Martínez, A., Ruiz, J., Martínez, J. A., Sánchez, M., Soriano, E., & Mensa, J. (2002). Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis. Journal of Antimicrobial Chemotherapy, 49(1), 55-59. https://doi.org/10.1093/jac/49.1.55

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title = "Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis",

abstract = "The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.",

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Horcajada, JP, Vila, J, Moreno-Martínez, A, Ruiz, J, Martínez, JA, Sánchez, M, Soriano, E & Mensa, J 2002, 'Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis', Journal of Antimicrobial Chemotherapy, vol. 49, no. 1, pp. 55-59. https://doi.org/10.1093/jac/49.1.55

Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis. / Horcajada, Juan P.; Vila, Jordi; Moreno-Martínez, Antonio et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 49, No. 1, 2002, p. 55-59.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis

AU - Horcajada, Juan P.

AU - Vila, Jordi

AU - Moreno-Martínez, Antonio

AU - Ruiz, Joaquim

AU - Martínez, Jose Antonio

AU - Sánchez, Miquel

AU - Soriano, Eladio

AU - Mensa, Josep

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N2 - The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.

AB - The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.

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M3 - Artículo

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AN - SCOPUS:0036153971

SN - 0305-7453

VL - 49

SP - 55

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis

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