Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers

Cristina Domingo, Fernando de Ory, Juan Carlos Sanz, Noelia Reyes, Joaquim Gascón, Ole Wichmann, Sabino Puente, Mirjam Schunk, Rogelio López-Vélez, Joaquim Ruiz, Antonio Tenorio

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25 Scopus citations


A total of 520 European travelers with suspected dengue fever were examined, and acute dengue virus infection was confirmed in 127 of them. Molecular and serological tests for dengue diagnosis, according to their usefulness in the different stages of the disease, were performed. The accuracy of the IgM/IgG ratio and the IgG avidity index was confirmed during the early phase of the illness to discriminate the serologic status (primary versus secondary immune response) of patients who were either naive or previously vaccinated against other flaviviruses. Virologic markers of secondary infection were detected in 11.8% of nonvaccinated infected patients and in 92.6% of yellow fever vaccinated patients. The proper use of these simple methodologies could help in the identification of patients affected with secondary infection, who may be at a higher risk of developing a hemorrhagic disorder.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Issue number1
StatePublished - Sep 2009


  • Avidity index
  • Dengue infection
  • Flavivirus vaccinated
  • IgM/IgG ratio
  • Prognostic marker
  • Secondary flavivirus infection
  • Serology


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