Mechanisms of resistance to quinolones: Target alterations, decreased accumulation and DNA gyrase protection

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Abstract

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.

Original languageEnglish
Pages (from-to)1109-1117
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number5
DOIs
StatePublished - 1 May 2003

Keywords

  • DNA gyrase
  • Efflux pumps
  • Quinolone resistance
  • Topoisomerase IV
  • qnr

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