Mecanismos moleculares de resistencia antibiótica en Escherichia coli asociadas a diarrea.

Translated title of the contribution: [Molecular mechanisms of antibiotic resistance in Escherichia coli- associated diarrhea].

Susan Mosquito, Joaquim Ruiz, José Luis Bauer, Theresa J. Ochoa

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Antibiotic resistance is an emerging problem worldwide present in many bacteria, specially in Escherichia coli, which has high percentages of resistance to ampicilline, thrimethoprim-sulfamethoxazole, tetracycline, chloramphenicol and nalidixic acid, which implies important complications in antibiotic treatment when required. The increasing antibiotic resistance is due to the acquisition of different molecular mechanisms of resistance through point chromosomal mutations and /or horizontal transfer of genetic material between related or different species facilitated by some genetic elements such as integrons. This review discusses the effects of the most common molecular mechanisms of antibiotic resistance in E. coli: enzymatic inactivation, changes in the target site and permeability disturbances. Getting to know the mechanisms of resistance which are involved, as the World Health Organization recommends, will allow us to improve the surveillance of the antibiotic resistance, the control policies and the antibiotic utilization at a national level.

Translated title of the contribution[Molecular mechanisms of antibiotic resistance in Escherichia coli- associated diarrhea].
Original languageSpanish
Pages (from-to)648-656
Number of pages9
JournalRevista Peruana de Medicina Experimental y Salud Publica
Volume28
Issue number4
StatePublished - Dec 2011

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