TY - JOUR
T1 - Low birth weight, preterm birth and small for gestational age association with adult depression
T2 - Systematic review and meta-analysis
AU - Loret De Mola, Christian
AU - De França, Giovanny Vinícius Araújo
AU - De Avila Quevedo, Luciana
AU - Horta, Bernardo Lessa
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: There is no consensus on the effects that low birth weight, premature birth and intrauterine growth have on later depression. Aims: To review systematically the evidence on the relationship of low birth weight, smallness for gestational age (SGA) and premature birth with adult depression. Method: We searched the literature for original studies assessing the effect of low birth weight, premature birth and SGA on adult depression. Separate meta-analyses were carried out for each exposure using random and fixed effects models. We evaluated the contribution of methodological covariates to heterogeneity using meta-regression. Results: We identified 14 studies evaluating low birth weight, 9 premature birth and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39, 95% CI 1.21-1.60). Premature birth and SGA were not associated with depression, but publication bias might have underestimated the effect of the former and only four studies evaluated SGA. Conclusions: Low birth weight was associated with depression. Future studies evaluating premature birth and SGA are needed.
AB - Background: There is no consensus on the effects that low birth weight, premature birth and intrauterine growth have on later depression. Aims: To review systematically the evidence on the relationship of low birth weight, smallness for gestational age (SGA) and premature birth with adult depression. Method: We searched the literature for original studies assessing the effect of low birth weight, premature birth and SGA on adult depression. Separate meta-analyses were carried out for each exposure using random and fixed effects models. We evaluated the contribution of methodological covariates to heterogeneity using meta-regression. Results: We identified 14 studies evaluating low birth weight, 9 premature birth and 4 SGA. Low birth weight increased the odds of depression (OR = 1.39, 95% CI 1.21-1.60). Premature birth and SGA were not associated with depression, but publication bias might have underestimated the effect of the former and only four studies evaluated SGA. Conclusions: Low birth weight was associated with depression. Future studies evaluating premature birth and SGA are needed.
UR - http://www.scopus.com/inward/record.url?scp=84909996650&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.113.139014
DO - 10.1192/bjp.bp.113.139014
M3 - Artículo
C2 - 25368358
AN - SCOPUS:84909996650
SN - 0007-1250
VL - 205
SP - 340
EP - 347
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 5
ER -